Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Ewing Sarcoma (classical)
- Radiologic Findings
- Fig 1A. Mass like opacity in right lower lung zone on chest PA
Fig 1B-E Well defined, ovoid shaped, and relatively homogeneous density mass (4.1 x 2.7 cm), based on the chest wall, right lower hemithorax. The mass shows obtuse angle with chest wall, suggesting extrapulmonary mass and there was no evidence of rib erosion .
The chest wall mass was diagnosed with classical Ewing sarcoma after biopsy.
Immunohistochemical staining results: CD99 (+, strongly membranous stain), Chromogranin (+), Synaptophysin (+), CD56 (+), NSE(-), CK (-), MyoD1 (-), Desmin (-), Alpha-SMA (-), LCA (-) on the tumor cells
- Brief Review
- Extraskeletal Ewing sarcoma involving the chest wall
[1] Askin tumor :extraskeletal Ewing sarcoma involving the chest wall, develop from embryonal migrating cells of the neural crest, large tumor involving the chest wall and pleura
[2] Karyotype abnormality with translocation involving chromosomes 11 and 22
[3] Histology :crowded sheets of small round blue cells
Radiographic Findings
Large, unilateral, extrapulmonary mass
Difficult to determine if mass originates from chest wall or pleura
Solid, compressing adjacent lung
With or without rib destruction (25-63%)
Rapid growth
Lymphadenopathy
Pleural effusion, frequent
Lung and bone metastases
Calcification, rare
- Please refer to
Case 202, Case 354, -
- References
- Murphey MD et al. From the Radiologic Pathology Archives: Ewing Sarcoma Family of Tumors: Radiologic-Pathologic Correlation. RadioGraphics 2013; 33:803–831
- Keywords
- Chest wall, Malignant tumor,